RNA Leaders USA Congress
September 10-11, 2025
Step into the Future of RNAi at RNA Leaders USA Congress
Connect with us
We’re excited to connect with you at RNA Leaders USA Congress! Don’t miss the chance to hear from our experts during the Keynote Panel on Oligo-Based Therapeutic Innovation and our standalone presentation on RNA Synthesis via Ligation.
Keynote Panel
Scaling Oligo-based Therapeutics with Innovation at the forefront
When: September 10, 2025, at 9:00am
Where: TBD
About the speaker
Alison Moore is Chief Technical Officer at Codexis, and has significant experience as a biopharmaceutical executive, including an extensive background in CMC product development and biomanufacturing. She will be participating in this panel with other industry experts.
Standalone talk
RNA Synthesis Using Ligation for Improved Scalability and Reduced Manufacturing Cost
In this 20-minute presentation Stefan Lutz, Ph.D., SVP of Research will discuss
- Discuss siRNA synthesis by assembly of multiple short, single-stranded RNA fragments into the desired double-stranded RNA duplex using ligation
-
Compare various ligation approaches with a particular focus on substrate design. In combination with double-stranded RNA ligase engineering and protocol optimization, such integrated process development can increase target drug substance yield and reduce manufacturing costs
-
Process performance will be demonstrated on the synthesis of a commercially approved siRNA asset
About the speaker
Dr. Stefan Lutz joined Codexis in 2020 as the Senior Vice President of Research to lead the company’s research team advancing the technology platform, as well as the discovery and engineering of novel enzymes for the Life Sciences and Pharma Manufacturing markets.
Future events
